Authors
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Kristina Andric
Department of Dermatovenerology, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia Centre for Dermatovenerology, University Clinical Centre Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.University Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia
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Vladimir Jakovljevic
Department of Physiology, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia Department of Human Pathology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
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Vladimir Zivkovic
Department of Physiology, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia Department of Pharmacology, First Moscow State Medical University, University I.M. Sechenov, Moscow, Russia
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Mirjana Veselinovic
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. Clinic for Rheumatology and Allergology, University Clinical Center Kragujevac, Kragujevac, Serbia.
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Sergey Bolevicg
Department of Human Pathology, I.M. Sechenov First Moscow State Medical University, Moscow
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Vladimir Petrovich Fisenko
Department of Pharmacology, First Moscow State Medical University, University I.M. Sechenov, Moscow, Russia
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Jovana Joksimovic Jovic
Department of Physiology, Faculty of Medical Sciences University of Kragujevac
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Marijana Andjic
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia Department of Pharmacy, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia
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Nevena Lazarevic
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia Department of Human Pathology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia Department of Pharmacy, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia
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Nikola Andric
Clinic for Orthopedics and Traumatology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia.
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Andjela Dimkic Milenkovic
Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, Pasterova 2, Belgrade, Serbia
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Dejan Vulovic
Department of Surgery, University of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69, 34000 Kragujevac, Serbia Centre for Plastic Surgery, University Clinical Centre Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.
Keywords:
Oxidative stress, Skin Transplantation, Galectin 3, Hand Injuries, Gender Differences
Abstract
The study included 40 patients of both genders who underwent skin transplantation after a hand injury. The study aims to evaluate the oxidative stress parameters in patients’ blood and serum levels of galectin-3 in order to investigate gender differences pre- and post- skin transplantation. The results of the study suggest a significant increase in superoxide anion radical levels, catalase activity, and reduced glutathione levels in females before skin transplantation. The surgical treatment caused significant increase in superoxide anion radical and hydrogen peroxide levels as prooxidants in males, while superoxide dismutase and catalase activity were also increased 7 days after the procedure. In females, superoxide anion radical and TBARS levels increased after surgical procedure as well as the activity of catalase. Regarding galectin-3 levels, a significant interaction between gender and time was observed (gender×time; p=0.000). Correlation analysis of different oxidative stress markers with gal-3 revealed the existence of a significant negative correlation of superoxide anion radical, catalase, and reduced glutathione with gal-3, but only in female patients. It can be concluded that OS as well as galectin-3 play important roles at least in the first 7 days of the postoperative period.
Section
Original Research Articles
License
Copyright (c) 2024 Kristina Andric, Vladimir Jakovljevic, Vladimir Zivkovic, Mirjana Veselinovic, Sergey Bolevicg, Vladimir Petrovich Fisenko, Jovana Joksimovic Jovic, Marijana Andjic, Nevena Lazarevic, Nikola Andric, Andjela Dimkic Milenkovic, Dejan Vulovic
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
