The role of metabolic disorders in the development of atherosclerosis

Role of metabolic disorders in atherosclerosis development

Authors

  • Alexander Blagov Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, Russia
  • Alexey Churov Pirogov Russian National Research Medical University,RussianGerontology Clinical Research Centre, Moscow, Institute on Aging Research, Russian Federation, 16 1st Leonova Street, 129226 Moscow, Russia
  • Alexander Golovyuk Vascular Surgery Department, A. V. Vishnevsky National Medical Research Center of Surgery, 27 Bolshaya Serpukhovskaya Street, 117997Moscow,Russia
  • Arthur Lee Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, Russia
  • Vasily Kashtalap Research Institute for Complex Issues of Cardiovascular Diseases, 6 Barbarash Boulevard, 650002 Kemerovo, Russia
  • Vasily Sukhorukov Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia
  • Alexander Orekhov Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia

Keywords:

atherosclerosis, inflammation, lipoproteins, metabolism

Abstract

Atherosclerosis is a major risk factor for cardiovascular disease (CVD), which is the leading cause of death worldwide. Atherosclerosis is initiated by endothelial activation, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification) triggering vasoconstriction and activation of inflammatory pathways. This review focuses on the various stages in the development of atherosclerosis, ranging from endothelial dysfunction to plaque rupture. In addition, disorders of lipid, glucose and amino acid metabolism in atherosclerosis are considered here. The key pathological stages of metabolism disruption and their role in atherosclerosis are considered in detail which may be helpful for the more better understanding of atherosclerosis pathogenesis. Finally, some therapeutic approaches aimed at modulating lipid metabolism will also be presented which show the therapeutic targets (enzymes and transport proteins) which modulation can prevent further deterioration of patients symptoms

Published

2024-10-31

Issue

Section

Reviews